Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MLYCD | O95822 | 2/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | DDO | Q99489 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658552 | 0.84 | CASP3 (0.34) | CASP3CYP2C9CYP2C19KDM4EMEN1 | |
| SCHEMBL7659400 | 0.83 | AKR1C3 (0.39) | CYP2C9CYP2C19KDM4EMEN1ALDH1A1 | |
| SCHEMBL7107198 | 0.79 | — | — | |
| SCHEMBL7106667 | 0.75 | KCNA5 (0.31) | MLYCD | |
| SCHEMBL7654556 | 0.74 | KMT2A (0.35) | CYP2C9CYP2C19KDM4EMEN1ALDH1A1 | |
| SCHEMBL30560902 | 0.74 | PARP1 (0.42) | CYP2C19MEN1KMT2APOLB | |
| SCHEMBL7650152 | 0.74 | MLYCD (0.42) | KDM4EALDH1A1MLYCDCFTR | |
| SCHEMBL6863468 | 0.74 | TSHR (0.31) | NTRK2 | |
| SCHEMBL1249570 | 0.74 | PARP1 (0.42) | CYP2C19MEN1KMT2APOLB | |
| SCHEMBL7650135 | 0.74 | NTRK2 (0.44) | CASP3CYP2C9CYP2C19KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |