Sugi Predict

Sugi Predict / Compounds / SCHEMBL7656309

SCHEMBL7656309

SCHEMBL7656309

O=Cc1cccc(CN2CCCCC2)c1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 3/20 0.58
▸ ALDH1A1 P00352 3/20 0.58
▸ TDP1 Q9NUW8 1/20 0.58
▸ CYP2D6 P10635 2/20 0.56
▸ CYP2C9 P11712 1/20 0.56
▸ HIF1A Q16665 1/20 0.56
▸ PRMT6 Q96LA8 1/20 0.56
▸ KDM4E B2RXH2 1/20 0.54
▸ GAA P10253 1/20 0.54
▸ HRH3 Q9Y5N1 3/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ ACHE P22303 2/20 0.49
▸ POLB P06746 1/20 0.47
▸ HTT P42858 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31528239 1.00 SMN1; SMN2 (0.58) SMN1; SMN2ALDH1A1TDP1CYP2D6CYP2C9
SCHEMBL3340879 0.98 PRMT6 (0.57) SMN1; SMN2ALDH1A1TDP1CYP2D6CYP2C9
SCHEMBL29442395 0.98 PRMT6 (0.57) SMN1; SMN2ALDH1A1TDP1CYP2D6CYP2C9
SCHEMBL3771382 0.87 ALDH1A1 (0.56) SMN1; SMN2ALDH1A1TDP1CYP2D6CYP2C9
SCHEMBL208910 0.85 NCF1 (0.62) SMN1; SMN2ALDH1A1KDM4EHRH3HTT
SCHEMBL31528286 0.85 NCF1 (0.62) SMN1; SMN2ALDH1A1KDM4EHRH3HTT
SCHEMBL31528202 0.84 MC4R (0.57) PRMT6HRH3
SCHEMBL2324451 0.84 SIGMAR1 (0.57) TDP1HRH3
SCHEMBL209815 0.84 MC4R (0.57) PRMT6HRH3
SCHEMBL13959137 0.84 HRH3 (0.58) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12281119-B2 Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist BEIGENE, LTD. (KY) 2025-04-22 — — US disclosed
EP-3921320-B1 IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST BEIGENE LTD (KY) 2024-03-06 — — EP disclosed
US-20220119394-A1 IMIDAZO[2,1-F][1,2,4]TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST BEONE MEDICINES I GMBH (CH) 2022-04-21 — — US disclosed
CN-113454086-A Imidazo [2,1-F ] [1,2,4] triazin-4-amine derivatives as TLR7 agonists 百济神州有限公司 2021-09-28 — — CN disclosed
US-9949968-B2 Diarylalkylamine REV-ERB antagonists and their use as medicaments FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2018-04-24 — — US disclosed
US-9949968-B2 Diarylalkylamine REV-ERB antagonists and their use as medicaments FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2018-04-24 — — US disclosed
US-9949968-B2 Diarylalkylamine REV-ERB antagonists and their use as medicaments FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2018-04-24 — — US disclosed
US-9932340-B2 Substituted indoles ABBVIE INC. (US) 2018-04-03 — — US disclosed
US-20170349589-A9 Substituted Indoles ABBVIE INC. (US) 2017-12-07 — — US disclosed
EP-3055293-B1 DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS FOND ST ITALIANO TECNOLOGIA (IT) 2017-12-06 — — EP disclosed
US-20140296220-A1 PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES ABBVIE INC (US) 2014-10-02 — — US disclosed
US-8796289-B2 Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases ABBVIE INC. (US) 2014-08-05 — — US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
WO-2013013031-A1 PYRIDAZINO [4, 5 -D] PYRIMIDIN- (6H) -ONE INHIBITORS OF WEE - 1 KINASE ABBVIE INC. (US) 2013-01-24 — — WO disclosed
US-20130023523-A1 PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES ABBOTT LABORATORIES (US) 2013-01-24 — — US disclosed
CN-101605767-A The method for preparing piperazinyl phenyl carboxamides derivatives and Diazesuberane yl-benzamide derivatives JANSSEN PHARMACEUTICA NV (BE) 2009-12-16 — — CN disclosed
CN-1277809-C Benzal indone and benzyl indone derivative(s), and its preparing method and use UNIV ZHEJIANG (CN) 2006-10-04 — — CN disclosed
CN-1709860-A Benzal indone and benzyl indone derivative(s), and its preparing method and use UNIV ZHEJIANG (CN) 2005-12-21 — — CN disclosed
WO-2002085861-A1 IMIDAZOLIDINE COMPOUNDS AND THEIR USE AS CXCR3 ANTAGONISTS MILLENNIUM PHARMACEUTICALS, INC. (US) 2002-10-31 — — WO disclosed
US-6469002-B1 COMPOUNDS WHICH MODULATE CHEMOKINE RECEPTOR ACTIVITY AND ARE USEFUL IN TREATMENT OF INFLAMMATORY DISEASES MILLENNIUM PHARMACEUTICALS, INC. 2002-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296220-A1 PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES WEE1, WEE2, CDK1 SMN1; SMN2 4219/4885ALDH1A1 1308/4885TDP1 640/4885
US-20220119394-A1 IMIDAZO[2,1-F][1,2,4]TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST TLR7, TLR1, TLR3 SMN1; SMN2 948/4885ALDH1A1 1611/4885TDP1 1177/4885
US-20170349589-A9 Substituted Indoles SUV39H2, SUV39H1, IDO1 SMN1; SMN2 1445/4885ALDH1A1 1752/4885TDP1 1440/4885
US-20130023523-A1 PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES WEE1, WEE2, CDK1 SMN1; SMN2 4219/4885ALDH1A1 1308/4885TDP1 640/4885
US-12281119-B2 Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist TLR7, TLR1, TLR3 SMN1; SMN2 948/4885ALDH1A1 1611/4885TDP1 1177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.