SCHEMBL7659834

SCHEMBL7659834

O=C(O)Cc1ccc2nc(Nc3cccnc3)oc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.52
NAPRT Q6XQN6 1/20 0.45
FAAH O00519 1/20 0.44
NPC1 O15118 4/20 0.43
ALDH1A1 P00352 3/20 0.43
RAB9A P51151 3/20 0.43
GAA P10253 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
PKM P14618 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HDAC6 Q9UBN7 2/20 0.41
MAPK1 P28482 1/20 0.41
IL6 P05231 1/20 0.41
STAT3 P40763 1/20 0.41
NAMPT P43490 2/20 0.40
POLB P06746 3/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 2/20 0.39
USP2 O75604 1/20 0.39
ESR1 P03372 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2437918 0.88 NPC1 (0.56) NPC1ALDH1A1RAB9AGAASMN1; SMN2
SCHEMBL7429665 0.82 NPC1 (0.53) KDM4ENPC1ALDH1A1RAB9AGAA
SCHEMBL7657273 0.80 EPHX2 (0.49) KDM4EALDH1A1HDAC6MAPK1POLB
SCHEMBL6614738 0.80 HDAC6 (0.53) NPC1ALDH1A1RAB9AGAASMN1; SMN2
SCHEMBL11640477 0.80 CSNK1D (0.49) NPC1ALDH1A1RAB9AGAASMN1; SMN2
SCHEMBL6165048 0.80 ALDH1A1 (0.41) KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL6170579 0.79 ITGB3 (0.39) KDM4ENPC1ALDH1A1RAB9APOLB
SCHEMBL14626860 0.79 NPC1 (0.54) NPC1ALDH1A1RAB9AGAASMN1; SMN2
SCHEMBL6593703 0.78 HDAC6 (0.62) KDM4ENPC1ALDH1A1RAB9AGAA
SCHEMBL6164392 0.78 FAAH (0.34) KDM4EFAAHNPC1ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144393-A3 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR AstraZeneca AB (SE) 2002-09-11 EP disclosed
US-6441012-B1 BENZOXAZOLE OR BENZTHIAZOLE DERIVATIVES FOR INHIBITING THE INTERACTION BETWEEN CELLULAR ADHESION MOLECULES AND/OR FIBRONECTIN AND THE INTERGRIN RECEPTOR ASTRAZENECA AB (SE) 2002-08-27 US disclosed
EP-1144393-A2 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR AstraZeneca AB (SE) 2001-10-17 EP disclosed
WO-2000005224-A2 HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITOR ASTRAZENECA AB (SE) 2000-02-03 WO disclosed