Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658278 | 0.94 | MAPT (0.52) | ADORA3MAPTPOLBTHRBALDH1A1 | |
| SCHEMBL7652545 | 0.92 | ADORA3 (0.49) | ADORA3MAPTADORA2AADORA2BALDH1A1 | |
| SCHEMBL7652943 | 0.83 | RPA1 (0.52) | ADORA3MAPTADORA2AALDH1A1TP53 | |
| SCHEMBL5820957 | 0.81 | TP53 (0.46) | ADORA3MAPTPOLBALDH1A1TP53 | |
| SCHEMBL7682175 | 0.79 | ALDH1A1 (0.55) | ADORA3MAPTALDH1A1 | |
| SCHEMBL7655309 | 0.79 | CA1 (0.45) | ADORA3MAPTPOLBALDH1A1TP53 | |
| SCHEMBL7649140 | 0.79 | TP53 (0.58) | ADORA3MAPTPOLBADORA2AALDH1A1 | |
| SCHEMBL7650590 | 0.79 | KDM4E (0.49) | MAPTPOLBADORA2AALDH1A1ADORA1 | |
| SCHEMBL7650966 | 0.78 | ADORA3 (0.45) | ADORA3MAPTADORA2AALDH1A1ADORA1 | |
| SCHEMBL7659194 | 0.77 | ALDH1A1 (0.51) | MAPTPOLBADORA2AADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |