Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.68 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.68 |
| ▸ | ITGAV | P06756 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348648 | 0.85 | ITGB3 (0.52) | ITGB3ITGA2BITGAVSMN1; SMN2MEN1 | |
| SCHEMBL7664581 | 0.84 | ITGB3 (0.64) | ITGB3ITGA2BITGAV | |
| SCHEMBL7651971 | 0.83 | ITGB3 (0.72) | ITGB3ITGA2BITGAV | |
| SCHEMBL26683376 | 0.83 | BCL2 (0.60) | SMN1; SMN2MEN1KMT2ACYP2C19HTT | |
| SCHEMBL7658155 | 0.82 | MEN1 (0.51) | ITGB3ITGA2BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7402105 | 0.81 | ITGB3 (1.00) | ITGB3ITGA2BITGAV | |
| SCHEMBL383058 | 0.81 | ITGB3 (0.58) | ITGB3ITGA2BITGAV | |
| SCHEMBL7654405 | 0.81 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL24620293 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2MEN1KMT2ACYP2C19HTT | |
| SCHEMBL8352940 | 0.79 | ITGB3 (0.79) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |