Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649050 | 0.77 | KDM4E (0.47) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7650665 | 0.71 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7652940 | 0.69 | KDM4E (0.51) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7652870 | 0.69 | KDM4E (0.44) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7654106 | 0.68 | MGLL (0.44) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7656605 | 0.68 | CXCR2 (0.67) | ADORA3CXCR2 | |
| SCHEMBL4965756 | 0.67 | MEN1 (0.50) | KDM4EMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL23401806 | 0.67 | MEN1 (0.50) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL23399793 | 0.67 | GAA (0.44) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7652834 | 0.66 | ALKBH5 (0.48) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |