Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209430 | 0.86 | MAPT (0.44) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2030465 | 0.79 | IDO1 (0.50) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL21765871 | 0.78 | HRH3 (0.42) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL131361 | 0.76 | ALDH1A1 (0.67) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL515186 | 0.76 | MAPT (0.56) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10299392 | 0.76 | IDO1 (0.52) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL776074 | 0.74 | LMNA (0.58) | TRPA1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL14899726 | 0.74 | MAPT (0.38) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13534963 | 0.74 | PRSS1 (0.44) | TSHRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL385188 | 0.74 | SLC6A4 (0.52) | TRPA1ALDH1A1TSHRMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019051222-A1 | BENZENE FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2019-03-14 | — | — | WO | disclosed |
| US-6384061-B1 | HYDANTOIN COMPOUNDS REPRESENTED BY FORMULA (I) WHICH SHOWS AN INHIBITORY ACTIVITY AGAINST FARNESYL TRANSFERASE, AND THUS CAN BE USED AS AN ANTI-CANCER AGENT, OR PHARMACEUTICALLY ACCEPTABLE SALTS | LG CHEMICAL LTD. (KR) | 2002-05-07 | — | — | US | disclosed |
| EP-1000036-A1 | HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE | LG CHEMICAL LIMITED (KR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005117-A1 | HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE | LG CHEMICAL LTD. (KR) | 1999-02-04 | — | — | WO | disclosed |