Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061648 | 0.87 | ALDH1A1 (0.42) | LMNAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL7655302 | 0.85 | CNR2 (0.50) | LMNAALDH1A1HPGDPOLBP2RX7 | |
| SCHEMBL7103645 | 0.83 | SCN10A (0.35) | LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL7658648 | 0.83 | LMNA (0.50) | LMNAALDH1A1HPGDPOLBP2RX7 | |
| SCHEMBL7110167 | 0.79 | ALDH1A1 (0.38) | ALDH1A1HPGDPOLBCNR2 | |
| SCHEMBL7104658 | 0.78 | SMN1; SMN2 (0.35) | LMNAALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL18157911 | 0.77 | KMT2A (0.61) | LMNAALDH1A1HPGDPOLBP2RX7 | |
| SCHEMBL7663610 | 0.77 | P2RX7 (0.44) | LMNAPOLBP2RX7KDM4EMEN1 | |
| SCHEMBL7663932 | 0.75 | ALDH1A1 (0.44) | LMNAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL7654754 | 0.74 | LMNA (0.66) | LMNAALDH1A1HPGDPOLBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |