SCHEMBL7659205

SCHEMBL7659205

CN(C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C)[C@@H](COCCO)Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 7/20 0.43
CTSB P07858 1/20 0.39
CTSS P25774 1/20 0.39
CTSK P43235 1/20 0.39
MAOB P27338 2/20 0.36
PPARG P37231 1/20 0.35
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
MMP9 P14780 1/20 0.35
MMP8 P22894 1/20 0.35
MMP13 P45452 1/20 0.35
ITGB3 P05106 1/20 0.35
ITGA2B P08514 1/20 0.35
REN P00797 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7659094 0.89 GHSR (0.42) GHSRCTSBCTSSCTSKMAOB
SCHEMBL8720198 0.86 GHSR (0.44) GHSRCTSBCTSSCTSKPPARG
SCHEMBL6317705 0.84 GHSR (0.48) GHSRCTSBCTSSCTSKMAOB
SCHEMBL7660973 0.83 L3MBTL1 (0.41) CTSBCTSSCTSKMAOBPPARA
SCHEMBL6317840 0.83 GHSR (0.38) GHSRCTSBCTSSCTSKMAOB
SCHEMBL7658685 0.82 GHSR (0.63) GHSRMAOBPPARGPPARDPPARA
SCHEMBL7658691 0.82 GHSR (0.63) GHSRMAOBPPARGPPARDPPARA
SCHEMBL3266843 0.82 GHSR (0.47) GHSRCTSBCTSSCTSKMAOB
SCHEMBL6318655 0.81 GHSR (0.44) GHSRCTSBCTSSCTSKMMP9
SCHEMBL7668217 0.81 GHSR (0.39) GHSRMAOBPPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed