Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670839 | 0.85 | CYP11B1 (0.41) | MAPTSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7664751 | 0.85 | HTR2A (0.40) | GRM5L3MBTL1 | |
| SCHEMBL7672934 | 0.82 | TTR (0.34) | MAPTLMNAGAANPSR1MEN1 | |
| SCHEMBL7664382 | 0.81 | SLC6A2 (0.43) | MAPTLMNANPSR1NPC1RAB9A | |
| SCHEMBL7664066 | 0.76 | BCL2L2 (0.37) | MAPTNPSR1HTTL3MBTL1 | |
| SCHEMBL7666933 | 0.76 | CYP11B1 (0.42) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7666947 | 0.74 | FEN1 (0.38) | MAPTNPSR1MEN1KMT2AHTT | |
| SCHEMBL7667019 | 0.70 | TRPA1 (0.41) | ALDH1A1HTTL3MBTL1 | |
| SCHEMBL14871868 | 0.68 | CYP1A2 (0.56) | MAPTSMN1; SMN2LMNACYP1A2CYP3A4 | |
| SCHEMBL7664578 | 0.68 | GRM5 (0.38) | MAPTSMN1; SMN2LMNAGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |