Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666947 | 0.84 | FEN1 (0.38) | BCL2L2FYNFEN1POLBALOX5AP | |
| SCHEMBL7664751 | 0.79 | HTR2A (0.40) | BCL2L2FEN1POLBALOX5APATM | |
| SCHEMBL7664372 | 0.76 | PLAU (0.41) | L3MBTL1MAPTHTTNPSR1 | |
| SCHEMBL7666782 | 0.76 | NPC1 (0.38) | BCL2L2FYNFEN1POLBALOX5AP | |
| SCHEMBL7670839 | 0.76 | CYP11B1 (0.41) | BCL2L2POLBATMLTA4HMAPT | |
| SCHEMBL7666933 | 0.76 | CYP11B1 (0.42) | BCL2L2FEN1LTA4HSREBF2CYP2D6 | |
| SCHEMBL7672934 | 0.74 | TTR (0.34) | BCL2L2FYNFEN1POLBALOX5AP | |
| SCHEMBL7664578 | 0.74 | GRM5 (0.38) | FEN1LTA4HMAPTBRD4 | |
| SCHEMBL7668578 | 0.72 | L3MBTL1 (0.36) | FEN1ALOX5APL3MBTL1SREBF2MAPT | |
| SCHEMBL7673906 | 0.72 | KEAP1 (0.39) | L3MBTL1SREBF2MAPTHTTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |