Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 6/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.38 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664066 | 0.84 | BCL2L2 (0.37) | FEN1ALOX5APBCL2L2FYNPOLB | |
| SCHEMBL7664751 | 0.77 | HTR2A (0.40) | FEN1ALOX5APBCL2L2POLBATM | |
| SCHEMBL7664372 | 0.74 | PLAU (0.41) | L3MBTL1MAPTHTTNPSR1MEN1 | |
| SCHEMBL7670839 | 0.74 | CYP11B1 (0.41) | BCL2L2POLBATMMAPTMEN1 | |
| SCHEMBL7666933 | 0.74 | CYP11B1 (0.42) | FEN1BCL2L2 | |
| SCHEMBL7668578 | 0.73 | L3MBTL1 (0.36) | FEN1ALOX5APL3MBTL1MAPTNPSR1 | |
| SCHEMBL7672934 | 0.72 | TTR (0.34) | FEN1ALOX5APBCL2L2FYNPOLB | |
| SCHEMBL7664578 | 0.72 | GRM5 (0.38) | FEN1MAPT | |
| SCHEMBL7673906 | 0.71 | KEAP1 (0.39) | L3MBTL1MAPTHTTNPSR1MEN1 | |
| SCHEMBL19612344 | 0.69 | NPSR1 (0.43) | POLBL3MBTL1HTTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |