Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 4/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666782 | 0.85 | NPC1 (0.38) | SLC6A4FEN1ALOX5APBCL2L2POLB | |
| SCHEMBL7670839 | 0.85 | CYP11B1 (0.41) | CYP11B1CYP11B2SYKBCL2L2POLB | |
| SCHEMBL7664372 | 0.85 | PLAU (0.41) | GRM5L3MBTL1 | |
| SCHEMBL7672934 | 0.82 | TTR (0.34) | SLC6A4FEN1ALOX5APBCL2L2POLB | |
| SCHEMBL7667019 | 0.82 | TRPA1 (0.41) | FEN1ALOX5APL3MBTL1 | |
| SCHEMBL7664066 | 0.79 | BCL2L2 (0.37) | SLC6A4FEN1ALOX5APBCL2L2POLB | |
| SCHEMBL7666933 | 0.78 | CYP11B1 (0.42) | GRM5FEN1CYP11B1CYP11B2BCL2L2 | |
| SCHEMBL7666947 | 0.77 | FEN1 (0.38) | FEN1ALOX5APBCL2L2POLBATM | |
| SCHEMBL7673906 | 0.72 | KEAP1 (0.39) | SLC6A4L3MBTL1ALOX15 | |
| SCHEMBL7668578 | 0.72 | L3MBTL1 (0.36) | FEN1ALOX5APL3MBTL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |