Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.38 |
| ▸ | FEN1 | P39748 | 6/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664751 | 0.82 | HTR2A (0.40) | L3MBTL1ALOX5APFEN1 | |
| SCHEMBL7664382 | 0.80 | SLC6A2 (0.43) | L3MBTL1SREBF2 | |
| SCHEMBL7673906 | 0.78 | KEAP1 (0.39) | L3MBTL1ALDH1A1HTTSREBF2 | |
| SCHEMBL7668578 | 0.76 | L3MBTL1 (0.36) | L3MBTL1ALOX5APFEN1ALDH1A1SREBF2 | |
| SCHEMBL7666933 | 0.75 | CYP11B1 (0.42) | FEN1ALDH1A1SREBF2 | |
| SCHEMBL7666782 | 0.70 | NPC1 (0.38) | L3MBTL1ALOX5APFEN1SREBF2 | |
| SCHEMBL7670839 | 0.70 | CYP11B1 (0.41) | ALDH1A1 | |
| SCHEMBL7664372 | 0.70 | PLAU (0.41) | L3MBTL1ALDH1A1HTT | |
| SCHEMBL15060590 | 0.69 | ALOX5AP (0.45) | L3MBTL1ALOX5APFEN1 | |
| SCHEMBL10462079 | 0.68 | PDE5A (0.41) | TRPA1ALOX5APFEN1BRD4SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |