Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.48 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665850 | 0.92 | ALDH1A1 (0.53) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL7665165 | 0.87 | OPRD1 (0.56) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL6167989 | 0.86 | LMNA (0.63) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL7668256 | 0.82 | OPRD1 (0.63) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL6598784 | 0.82 | LMNA (0.49) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL7820476 | 0.80 | L3MBTL1 (0.54) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL6171747 | 0.80 | LMNA (0.52) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL6170025 | 0.79 | LMNA (0.52) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL6599092 | 0.78 | LMNA (0.55) | LMNAALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL7666972 | 0.78 | ALDH1A1 (0.45) | LMNAALDH1A1OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |