Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662199 | 0.88 | DRD2 (0.54) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6847617 | 0.86 | DRD2 (0.59) | DRD2CCNT1CDK9 | |
| SCHEMBL7661469 | 0.80 | ADRA1A (0.59) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL6848549 | 0.77 | CCR2 (0.50) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL23595887 | 0.76 | HTR2A (0.62) | ADRA1DADRA1AADRA1BADRA2AHRH1 | |
| SCHEMBL7531578 | 0.76 | ADRA1A (0.59) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL14619656 | 0.75 | DRD2 (0.60) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL230687 | 0.75 | HTR2A (0.56) | DRD2 | |
| SCHEMBL7966008 | 0.75 | DRD2 (0.72) | DRD2 | |
| SCHEMBL6848950 | 0.75 | DRD2 (0.55) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | disclosed |
| US-6319932-B1 | USEFUL FOR TREATING BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-11-20 | — | — | US | disclosed |
| US-6235759-B1 | BENIGN PROSTATIC HYPERPLASIA; HYPOTENSIVE AGENTS | MERCK & CO., INC. | 2001-05-22 | — | — | US | disclosed |
| US-6228870-B1 | BENIGN PROSTATIC HYPERPLASIA; REDUCTION OF HYPOTENSION SIDE EFFECT | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |
| WO-2000027827-A1 | OXAZOLIDINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000027817-A1 | OXAZOLIDINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |