Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | DHPS | P49366 | 3/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670809 | 0.79 | S1PR4 (0.40) | L3MBTL1HPGDMAPTRAB9AGAA | |
| SCHEMBL7668470 | 0.76 | KEAP1 (0.46) | L3MBTL1MAPTMAPK1ALDH1A1RAB9A | |
| SCHEMBL7666314 | 0.76 | L3MBTL1 (0.49) | L3MBTL1MAPTMAPK1ALDH1A1RAB9A | |
| SCHEMBL7674060 | 0.75 | S1PR4 (0.50) | HPGDMAPTALDH1A1LMNAHTT | |
| SCHEMBL7666779 | 0.75 | HTR2A (0.44) | L3MBTL1HPGDMAPTMAPK1ALDH1A1 | |
| SCHEMBL7668891 | 0.72 | HTR2A (0.41) | L3MBTL1MAPTMAPK1ALDH1A1NPSR1 | |
| SCHEMBL7662189 | 0.72 | L3MBTL1 (0.38) | L3MBTL1MAPTMAPK1ALDH1A1RAB9A | |
| SCHEMBL7665088 | 0.72 | NPSR1 (0.40) | MAPTALDH1A1POLBNPSR1KDM4E | |
| SCHEMBL7664554 | 0.72 | ALDH1A1 (0.47) | MAPTMAPK1ALDH1A1GAAKDM4E | |
| SCHEMBL29581181 | 0.72 | HPGD (0.40) | HPGDMAPTMAPK1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |