Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667376 | 0.79 | L3MBTL1 (0.39) | KDM4ELMNACYP1A2CYP2C19NPSR1 | |
| SCHEMBL7664278 | 0.76 | CYP1A2 (0.46) | KDM4ECYP1A2CYP2C19NPSR1L3MBTL1 | |
| SCHEMBL7673688 | 0.75 | ESRRA (0.46) | KDM4ELMNACYP1A2NPSR1L3MBTL1 | |
| SCHEMBL10868317 | 0.74 | GRM5 (0.41) | KDM4ELMNACYP1A2CYP2C19NPSR1 | |
| SCHEMBL7663772 | 0.74 | S1PR4 (0.56) | S1PR4LMNAHPGDSLC6A2HSP90AA1 | |
| SCHEMBL7672764 | 0.73 | HTR2A (0.46) | S1PR4KDM4ECYP1A2CYP2C19NPSR1 | |
| SCHEMBL7226169 | 0.72 | ALDH1A1 (0.42) | S1PR4KDM4ECYP1A2CYP2C19NPSR1 | |
| SCHEMBL1182171 | 0.71 | ALDH1A1 (0.39) | KDM4ELMNACYP1A2CYP2C19NPSR1 | |
| SCHEMBL7667163 | 0.71 | ALDH1A1 (0.47) | S1PR4KDM4ELMNANPSR1L3MBTL1 | |
| SCHEMBL7668427 | 0.71 | ADORA2A (0.42) | S1PR4CYP2C19GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |