Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.52 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690859 | 0.89 | MEP1B (0.62) | F2TMPRSS6MEP1BCYP2C19AKR1C3 | |
| SCHEMBL782653 | 0.88 | F2 (0.53) | F2TMPRSS6MEP1BSLC40A1ACLY | |
| SCHEMBL7673504 | 0.84 | ALDH1A1 (0.54) | F2TMPRSS6MEP1BMAPTHPGD | |
| SCHEMBL7671933 | 0.82 | F2 (0.56) | F2TMPRSS6 | |
| SCHEMBL28588397 | 0.81 | ALDH1A1 (0.51) | MEP1BHPGDALDH1A1POLBCYP2C19 | |
| SCHEMBL7586096 | 0.80 | F2 (0.52) | F2TMPRSS6LMNAALDH1A1STAT3 | |
| SCHEMBL7674833 | 0.79 | ACLY (0.43) | F2TMPRSS6BRD4SLC40A1ACLY | |
| SCHEMBL7671455 | 0.78 | ACLY (0.41) | F2TMPRSS6BRD4SLC40A1ACLY | |
| SCHEMBL781871 | 0.78 | F2 (0.42) | F2TMPRSS6BRD4SLC40A1ACLY | |
| SCHEMBL25203341 | 0.78 | PTPRC (0.57) | LMNAMAPTHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |