Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673281 | 0.87 | CA12 (0.42) | KDM4EHSD17B10 | |
| SCHEMBL7666493 | 0.71 | GABRA1 (0.40) | CHRM1VKORC1ALOX5GUSBCYP1B1 | |
| SCHEMBL28866010 | 0.70 | FLT1 (0.44) | POLBATMGAAMAPTGUSB | |
| SCHEMBL9025088 | 0.68 | ALDH1A1 (0.40) | KDM4E | |
| SCHEMBL7670714 | 0.68 | KCNH2 (0.39) | CHRM1VKORC1ALOX5GUSBKDM4E | |
| SCHEMBL8144941 | 0.66 | CYP19A1 (0.38) | VKORC1MAPTCYP1B1KDM4EGABRA1 | |
| SCHEMBL6976958 | 0.65 | GUSB (0.37) | CHRM1VKORC1ALOX5GUSBCYP1B1 | |
| SCHEMBL6984153 | 0.65 | ADORA2A (0.38) | CHRM1VKORC1ALOX5GUSBKDM4E | |
| SCHEMBL8153648 | 0.65 | VKORC1 (0.40) | CHRM1VKORC1GUSBKDM4EGABRA1 | |
| SCHEMBL12955389 | 0.64 | AR (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |