Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 6/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023936 | 0.82 | NQO2 (0.34) | ALDH1A1P2RX4GLAPARP1CYP1A2 | |
| SCHEMBL9024823 | 0.81 | P2RX4 (0.36) | ALDH1A1P2RX4GLADHFRPARP1 | |
| SCHEMBL9023550 | 0.81 | G6PD (0.46) | ALDH1A1GLAPARP1CYP1A2HPGD | |
| SCHEMBL9024487 | 0.80 | ABCB1 (0.42) | ALDH1A1P2RX4GLASLC6A4SLC6A2 | |
| SCHEMBL9024240 | 0.78 | KDM1A (0.38) | P2RX4PARP1KCNA3NQO1NQO2 | |
| SCHEMBL2725699 | 0.77 | NQO1 (0.39) | ALDH1A1P2RX4GLAKDM4ENQO1 | |
| SCHEMBL9025371 | 0.76 | CYP1A2 (0.44) | ALDH1A1P2RX4GLAPARP1CYP1A2 | |
| SCHEMBL9738372 | 0.74 | NQO2 (0.46) | ALDH1A1PARP1HPGDKDM4ENQO1 | |
| SCHEMBL7673281 | 0.74 | CA12 (0.42) | ALDH1A1P2RX4PARP1CYP1A2HPGD | |
| SCHEMBL9023887 | 0.73 | GLA (0.47) | ALDH1A1P2RX4GLACYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |