Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668385 | 0.87 | POLB (0.41) | KDM4EHSD17B10 | |
| SCHEMBL9025088 | 0.74 | ALDH1A1 (0.40) | PARP1P2RX4KDM4ECYP1A2TDP1 | |
| SCHEMBL9025371 | 0.68 | CYP1A2 (0.44) | TSHRPARP1P2RX4KDM4ECYP1A2 | |
| SCHEMBL9023887 | 0.68 | GLA (0.47) | TSHRP2RX4KDM4ECYP1A2CYP2C9 | |
| SCHEMBL9024823 | 0.68 | P2RX4 (0.36) | PARP1P2RX4KDM4ECYP1A2TDP1 | |
| SCHEMBL9024487 | 0.67 | ABCB1 (0.42) | TSHRP2RX4KDM4EALDH1A1NQO1 | |
| SCHEMBL7674661 | 0.64 | DUSP3 (0.40) | PARP1KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28868393 | 0.64 | MCL1 (0.44) | TSHRPARP1ARCYP19A1PTPN1 | |
| SCHEMBL7668624 | 0.64 | P2RX4 (0.47) | P2RX4HDAC6KDM4EALDH1A1HPGD | |
| SCHEMBL27917591 | 0.63 | MCL1 (0.62) | P2RX4KDM4ECYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |