Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573216 | 0.87 | TPMT (0.52) | TPMTHSD17B10TSHRALDH1A1CA12 | |
| SCHEMBL3546802 | 0.85 | TPMT (0.79) | TPMTKMT2AHSD17B10NCOA1NCOA3 | |
| SCHEMBL24526816 | 0.79 | LMNA (0.49) | TPMTHSD17B10TSHRHTTLMNA | |
| SCHEMBL14907059 | 0.79 | NCOA1 (0.76) | TPMTKMT2AHSD17B10NCOA1NCOA3 | |
| SCHEMBL1204414 | 0.79 | HTT (0.72) | TPMTKMT2AHSD17B10NCOA1NCOA3 | |
| SCHEMBL30740894 | 0.79 | HTT (0.72) | TPMTKMT2AHSD17B10NCOA1NCOA3 | |
| SCHEMBL1560980 | 0.77 | TPMT (0.67) | TPMTKMT2AHSD17B10NCOA1NCOA3 | |
| SCHEMBL21837048 | 0.77 | TPMT (0.67) | TPMTKMT2AHSD17B10TSHRAPOBEC3A | |
| SCHEMBL31318522 | 0.77 | TPMT (0.67) | TPMTKMT2AHSD17B10TSHRAPOBEC3A | |
| SCHEMBL31063258 | 0.77 | TPMT (0.67) | TPMTKMT2AHSD17B10NCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444670-B2 | ENZYME INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES; ANTI-DIABETIC AGENTS; TREATMENT OF INSULIN RESISTANCE ASSOCIATED WITH OBESITY, GLUCOSE INTOLERANCE, DIABETES MELLITUS, HYPERTENSION AND ISCHEMIC DISEASES OF VESSELS | WYETH | 2002-09-03 | — | — | US | disclosed |
| US-20020002187-A1 | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin-resistance and hyperglycemia | WYETH | 2002-01-03 | — | — | US | disclosed |
| CN-1308625-A | Naphtho [2, 3-B ] heteroar-4-yl derivatives | AMERICAN HOME PROD (US) | 2001-08-15 | — | — | CN | disclosed |
| CN-1308626-A | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PROD (US) | 2001-08-15 | — | — | CN | disclosed |
| US-6251936-B1 | ADMINISTERING TO THE PATIENT SUFFERING FROM METABOLIC DISORDERS MEDIATED BY INSULIN RESISTANCE OR HYPERGLYCEMIA A BENZENE OR PYRIDINE SUBSTITUTED INDOLE OR BENZOTHIOPHENE DERIVATIVES OR SALTS | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-26 | — | — | US | disclosed |
| EP-1077969-A1 | BENZOTHIOPHENES, BENZOFURANS, AND INDOLES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| EP-1077968-A1 | NAPHTHO[2,3-B]HETEROAR-4-YL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6121271-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999061435-A1 | BENZOTHIOPHENES, BENZOFURANS, AND INDOLES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1999058522-A1 | NAPHTHO[2,3-B]HETEROAR-4-YL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002187-A1 | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin-resistance and hyperglycemia | IRS1, INSR, GPR119 | TPMT 1640/4885KMT2A 2872/4885HSD17B10 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.