Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671404 | 0.88 | GPR17 (0.59) | MEN1KMT2ASTAT3LMNANPC1 | |
| SCHEMBL7668016 | 0.88 | GPR17 (0.58) | MEN1KMT2ASTAT3LMNANPC1 | |
| SCHEMBL7667906 | 0.87 | KMT2A (0.56) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL7582747 | 0.87 | LMNA (0.65) | MEN1KMT2ALMNAF2ALDH1A1 | |
| SCHEMBL7672669 | 0.87 | LMNA (0.62) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL7668179 | 0.85 | KMT2A (0.59) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL7665938 | 0.83 | MEN1 (0.66) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL7663141 | 0.83 | GPR27 (0.59) | MEN1KMT2ASTAT3LMNANPC1 | |
| SCHEMBL7663740 | 0.82 | ALDH1A1 (0.65) | MEN1KMT2ALMNAF2ALDH1A1 | |
| SCHEMBL7670521 | 0.82 | MEN1 (0.57) | MEN1KMT2ALMNAF2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |