Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674300 | 0.94 | CTSL (0.50) | CDK2PDGFRACCNE1PDE4BPDE4D | |
| SCHEMBL7358873 | 0.88 | CTSL (0.46) | CDK2PDGFRACCNE1CTSLCDK1 | |
| SCHEMBL7661515 | 0.88 | CCNE1 (0.54) | CDK2PDGFRACCNE1CTSLCDK1 | |
| SCHEMBL7670599 | 0.87 | CTSL (0.42) | KDM4ENFKB1CDK2PDGFRACCNE1 | |
| SCHEMBL7674135 | 0.87 | PDGFRA (0.43) | CDK2PDGFRACCNE1PDE4BPDE4D | |
| SCHEMBL7666144 | 0.84 | CDK4 (0.45) | KDM4ECDK2PDGFRACCNE1CTSL | |
| SCHEMBL7674302 | 0.84 | PDGFRA (0.44) | CDK2PDGFRACCNE1CTSLCDK1 | |
| SCHEMBL7672863 | 0.84 | PDGFRA (0.52) | CDK2PDGFRACCNE1 | |
| SCHEMBL7667683 | 0.84 | CCNE1 (0.55) | KDM4ENFKB1CDK2PDGFRACCNE1 | |
| SCHEMBL7668634 | 0.84 | CCNE1 (0.54) | CDK2PDGFRACCNE1CTSLCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |