Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 4/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667052 | 0.92 | LTA4H (0.45) | KDM4EPOLBGAALTA4HSIGMAR1 | |
| SCHEMBL7673385 | 0.90 | LTA4H (0.42) | KDM4EPOLBGAALTA4HHRH3 | |
| SCHEMBL7664000 | 0.86 | LTA4H (0.45) | KDM4EPOLBGAALTA4HPTGS2 | |
| SCHEMBL8132685 | 0.84 | LTA4H (0.39) | GAALTA4HHPGDBCHE | |
| SCHEMBL7669105 | 0.84 | PTGDR2 (0.31) | — | |
| SCHEMBL7668910 | 0.83 | MEN1 (0.42) | KDM4EPOLBGAALTA4HPTGS2 | |
| SCHEMBL7668342 | 0.82 | PKM (0.34) | — | |
| SCHEMBL7669192 | 0.79 | PTGDR2 (0.32) | — | |
| SCHEMBL7666718 | 0.78 | SIGMAR1 (0.43) | KDM4EPOLBGAALTA4HPTGS2 | |
| SCHEMBL7670903 | 0.78 | FPR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |