Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667163 | 0.87 | ALDH1A1 (0.47) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7667111 | 0.86 | HTR2A (0.43) | HTR2ASLC6A4KCNH2MEN1CYP1A2 | |
| SCHEMBL7666787 | 0.86 | MAPT (0.43) | HTR2ASLC6A4KCNH2MEN1ALDH1A1 | |
| SCHEMBL22199135 | 0.85 | S1PR4 (0.51) | HTR2ASLC6A4KCNH2KDM4EMEN1 | |
| SCHEMBL7659649 | 0.82 | ADORA1 (0.34) | HTR2ASLC6A4KCNH2S1PR4 | |
| SCHEMBL7666779 | 0.79 | HTR2A (0.44) | HTR2ASLC6A4KCNH2KDM4EMEN1 | |
| SCHEMBL7663772 | 0.79 | S1PR4 (0.56) | SLC6A4MAPTHPGDS1PR4PTGS1 | |
| SCHEMBL3949976 | 0.75 | TGFBR1 (0.41) | S1PR4SCN5ASCN9A | |
| SCHEMBL7671126 | 0.75 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7226169 | 0.74 | ALDH1A1 (0.42) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |