Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672764 | 0.87 | HTR2A (0.46) | ALDH1A1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL7667111 | 0.84 | HTR2A (0.43) | MEN1KMT2AL3MBTL1S1PR4LMNA | |
| SCHEMBL7666787 | 0.84 | MAPT (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL7666314 | 0.82 | L3MBTL1 (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL7226169 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7659649 | 0.80 | ADORA1 (0.34) | S1PR4 | |
| SCHEMBL7666779 | 0.74 | HTR2A (0.44) | ALDH1A1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL3949976 | 0.73 | TGFBR1 (0.41) | S1PR4 | |
| SCHEMBL7671126 | 0.73 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNASYKHTT | |
| SCHEMBL22199135 | 0.73 | S1PR4 (0.51) | ALDH1A1MEN1KMT2ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |