Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632592 | 0.86 | CTNNB1 (0.52) | KDM4EALDH1A1MEN1KMT2AEGLN2 | |
| SCHEMBL29902970 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1MEN1KMT2AEGLN2 | |
| SCHEMBL11772465 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1MEN1KMT2AEGLN2 | |
| SCHEMBL11269818 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1MEN1KMT2AEGLN2 | |
| SCHEMBL1505243 | 0.82 | LOXL2 (0.56) | ALDH1A1MEN1KMT2ACA12CA1 | |
| SCHEMBL1398937 | 0.82 | CTNNB1 (0.56) | KDM4EMEN1KMT2APARP1NPC1 | |
| SCHEMBL25911130 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1MEN1KMT2AEGLN2 | |
| SCHEMBL16871506 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL2057210 | 0.81 | ERCC5 (0.63) | KDM4EALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL2130116 | 0.81 | CES2 (0.62) | ALDH1A1MEN1KMT2APARP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441173-B1 | NOVEL INTERMEDIATES OF AND CONVERSION TO 3-(2-(2-HYDROXYETH-1-YLOXY) OR (2-CARBOXYMETHOXY)-4-METHOXYPHENYL)-1-(3,4-METHYLENE DIOXYPHENYL)-5-(PROP-1-YLOXY)INDANE-2-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION | 2002-08-27 | — | — | US | disclosed |
| EP-0876352-A4 | PROCESS | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | EP | disclosed |
| US-6114549-A | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0876352-A1 | PROCESS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997017330-A1 | PROCESS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |