Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670021 | 0.87 | MMP13 (0.59) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL4293137 | 0.80 | EHMT2 (0.45) | MMP2MMP9S1PR5POLBMEN1 | |
| SCHEMBL1613647 | 0.73 | GAA (0.58) | HTTPOLBALDH1A1P2RX7MEN1 | |
| SCHEMBL18204743 | 0.73 | GAA (0.58) | HTTPOLBALDH1A1P2RX7MEN1 | |
| SCHEMBL289716 | 0.73 | GAA (0.58) | HTTPOLBALDH1A1P2RX7MEN1 | |
| SCHEMBL6691597 | 0.72 | MMP13 (0.77) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7672124 | 0.72 | MMP13 (0.77) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7624130 | 0.69 | P2RX7 (0.55) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL24856527 | 0.68 | MMP2 (0.44) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL3401232 | 0.68 | LTA4H (0.43) | MMP2MMP13MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458822-B2 | (4R)-1-(4-(4-FLUOROPHENOXY)BENZYL)-2-OXO-IMIDAZOLIDINE-4 -CARBOXYLIC ACID HYDROXYAMIDE, FOR EXAMPLE; TREATING VARIOUS DISEASES INCLUDING OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CANCER, OSTEOPOROSIS, STROKES | PFIZER INC. | 2002-10-01 | — | — | US | disclosed |