Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CBR1 | P16152 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670984 | 0.79 | LOXL2 (0.43) | KDM4EMAPTLMNALOXL2JAK2 | |
| SCHEMBL7668527 | 0.76 | TRPA1 (0.45) | SLC6A2SLC6A3SLC6A4LOXL2ALDH1A1 | |
| SCHEMBL7667320 | 0.76 | LOXL2 (0.43) | KDM4EMAPTLMNALOXL2ALDH1A1 | |
| SCHEMBL7661911 | 0.74 | LOXL2 (0.42) | KDM4ESLC6A3MAPTHPGDLOXL2 | |
| SCHEMBL7186092 | 0.71 | TTR (0.75) | SLC6A2SLC6A3MAPTNR1I2LMNA | |
| SCHEMBL7662088 | 0.71 | L3MBTL1 (0.40) | KDM4EMAPTLMNAHPGDLOXL2 | |
| SCHEMBL7671893 | 0.71 | LOXL2 (0.39) | MAPTSLC6A4LOXL2ALDH1A1GAA | |
| SCHEMBL7674113 | 0.71 | ALOX5 (0.41) | KDM4EMAPTLMNALOXL2ALDH1A1 | |
| SCHEMBL7662066 | 0.70 | LOXL2 (0.41) | KDM4EMAPTLMNAHPGDPTGS1 | |
| SCHEMBL7659816 | 0.70 | ESR1 (0.44) | MAPTPTGS2LOXL2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |