Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | CCND2 | P30279 | 2/20 | 0.45 |
| ▸ | CCND3 | P30281 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.44 |
| ▸ | CDK2 | P24941 | 8/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672132 | 0.91 | GALR2 (0.44) | PDGFRACCNE1CDK2CTSLMAPT | |
| SCHEMBL7674300 | 0.86 | CTSL (0.50) | CDK4CCND1CCND2CCND3PDGFRA | |
| SCHEMBL7358873 | 0.85 | CTSL (0.46) | PDGFRACCNE1CDK2CTSLPOLA1 | |
| SCHEMBL7661515 | 0.85 | CCNE1 (0.54) | CDK4CCND1CCND2CCND3PDGFRA | |
| SCHEMBL7673595 | 0.84 | KDM4E (0.45) | PDGFRACCNE1CDK2CTSLMAPT | |
| SCHEMBL7674302 | 0.83 | PDGFRA (0.44) | PDGFRACCNE1CDK2CTSLMEN1 | |
| SCHEMBL7672897 | 0.83 | LMNA (0.50) | PDGFRACCNE1CDK2MAPTMEN1 | |
| SCHEMBL7671191 | 0.83 | GBA1 (0.48) | PDGFRACCNE1CDK2CTSLMAPT | |
| SCHEMBL7666120 | 0.82 | PDGFRA (0.49) | PDGFRACCNE1CDK2CTSLMAPT | |
| SCHEMBL7674135 | 0.82 | PDGFRA (0.43) | PDGFRACCNE1CDK2CTSLPOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |