Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | MMP1 | P03956 | 6/20 | 0.51 |
| ▸ | MMP2 | P08253 | 6/20 | 0.51 |
| ▸ | MMP9 | P14780 | 6/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673769 | 1.00 | MEN1 (0.52) | MEN1KMT2AEGFRMMP1MMP2 | |
| SCHEMBL4832364 | 0.84 | MMP1 (0.60) | MEN1KMT2AEGFRMMP1MMP2 | |
| SCHEMBL4832357 | 0.84 | MMP1 (0.60) | MEN1KMT2AEGFRMMP1MMP2 | |
| SCHEMBL7669640 | 0.83 | GHSR (0.53) | MEN1KMT2AMAPTTP53CA1 | |
| SCHEMBL7582747 | 0.81 | LMNA (0.65) | MEN1KMT2AMMP2MMP9SMN1; SMN2 | |
| SCHEMBL28588397 | 0.80 | ALDH1A1 (0.51) | MEN1KMT2AMMP1MMP2MMP9 | |
| SCHEMBL7667889 | 0.79 | PRMT1 (0.57) | MEN1KMT2AMAPTSMN1; SMN2CA1 | |
| SCHEMBL7671582 | 0.79 | ALDH1A1 (0.50) | MEN1KMT2AMAPTTP53KDM4E | |
| SCHEMBL7663139 | 0.79 | POLB (0.62) | MEN1KMT2AMMP1MMP2MMP9 | |
| SCHEMBL7663740 | 0.79 | ALDH1A1 (0.65) | MEN1KMT2ASMN1; SMN2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |