SCHEMBL767500

SCHEMBL767500

Nc1cccc2c1C(=O)N(N)C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA1A P0DMV8 1/20 0.56
PABPC1 P11940 1/20 0.56
DPP4 P27487 1/20 0.53
ADORA2A P29274 3/20 0.51
PTPRC P08575 1/20 0.50
MPO P05164 1/20 0.49
KDM4E B2RXH2 6/20 0.45
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
F2 P00734 1/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.45
MAPK1 P28482 1/20 0.45
FGR P09769 1/20 0.45
PIM1 P11309 1/20 0.45
MAOA P21397 1/20 0.45
CSNK1A1 P48729 1/20 0.45
CSNK1D P48730 1/20 0.45
DYRK1A Q13627 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24421365 0.81 DPP4 (0.51) DPP4MPOKMT2AMEN1ALDH1A1
SCHEMBL7568712 0.79 DDB1 (0.43) HSPA1APABPC1DPP4MPOKMT2A
SCHEMBL9450349 0.79 KDM4E (0.43) HSPA1APABPC1ADORA2AMPOKDM4E
SCHEMBL11214758 0.77 HSPA1A (0.55) HSPA1APABPC1DPP4ADORA2APTPRC
SCHEMBL2036747 0.77 MEN1 (0.58) HSPA1APABPC1DPP4ADORA2APTPRC
SCHEMBL43760 0.77 PABPC1 (0.55) HSPA1APABPC1DPP4ADORA2APTPRC
SCHEMBL626365 0.76 MPO (0.48) PTPRCMPOKDM4EKMT2AMEN1
SCHEMBL29448054 0.76 MPO (0.48) PTPRCMPOKDM4EKMT2AMEN1
Hydrochloric Acid SCHEMBL10728562 0.74 MPO (0.47) PTPRCMPOKDM4EKMT2AMEN1
SCHEMBL19370912 0.74 HSPA1A (0.51) HSPA1APABPC1DPP4ADORA2APTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118271901-A Alcohol-soluble environment-friendly printing ink and preparation method thereof 厦门欧化实业有限公司 2024-07-02 CN claimed
EP-2373329-A2 USE OF EPIDERMAL GROWTH FACTOR INHIBITORS IN THE TREATMENT OF VIRAL INFECTION The Regents of the University of California (US) 2011-10-12 EP claimed
US-20110236349-A1 Use of Epidermal Growth Factor Inhibitors in the Treatment of Viral Infection THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2011-09-29 US claimed
WO-2010123527-A2 USE OF EPIDERMAL GROWTH FACTOR INHIBITORS IN THE TREATMENT OF VIRAL INFECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-10-28 WO claimed
WO-1997043643-A1 INHIBITORS OF PSEUDOMONAS AERUGINOSA INDUCED MUCIN PRODUCTION: COMPOSITIONS AND TREATMENTS FOR CYSTIC FIBROSIS PATIENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-11-20 WO claimed
JP-5163240-A None JP disclosed
CN-118271901-A Alcohol-soluble environment-friendly printing ink and preparation method thereof 厦门欧化实业有限公司 2024-07-02 CN disclosed
EP-2066673-B1 TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS CHEMBRIDGE CORP (US) 2016-12-28 EP disclosed
US-9290503-B2 Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders CHEMBRIDGE CORPORATION (US) 2016-03-22 US disclosed
US-9249147-B2 Tyrosine kinase inhibitors CHEMBRIDGE CORPORATION (US) 2016-02-02 US disclosed
EP-2966076-A1 NOVEL TYROSINE KINASE INHIBITORS ChemBridge Corporation (US) 2016-01-13 EP disclosed
CN-102036990-B Novel tyrosine kinase inhibitors CHEMBRIDGE CORP. (US) 2015-09-30 CN disclosed
CN-1102643-A Substituted derivatives of diaminophthalimide CIBA GEIGY AG (CH) 1995-05-17 CN disclosed
CN-1102643-A Substituted derivatives of diaminophthalimide CIBA GEIGY AG (CH) 1995-05-17 CN disclosed
EP-0516588-B1 Substituted diaminophtalimides and analogues CIBA GEIGY AG (CH) 1994-07-13 EP disclosed
EP-0600830-A1 Substituted derivatives of diaminophthalimide as protein-tyrosine kinase inhibitors CIBA-GEIGY AG (CH) 1994-06-08 EP disclosed
JP-H05163240-A SUBSTITUTED DIAMINOPHTHALIMIDE AND ANALOGUE CIBA GEIGY AG 1993-06-29 JP disclosed
CN-1067052-A The diaminophthalimides and the analogue thereof that replace CIBA GEIGY AG (CH) 1992-12-16 CN disclosed
CN-1067052-A The diaminophthalimides and the analogue thereof that replace CIBA GEIGY AG (CH) 1992-12-16 CN disclosed
EP-0516588-A1 Substituted diaminophtalimides and analogues CIBA-GEIGY AG (CH) 1992-12-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110236349-A1 Use of Epidermal Growth Factor Inhibitors in the Treatment of Viral Infection EGFR, HDGF, HGF HSPA1A 1233/4885PABPC1 2148/4885DPP4 1612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.