Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678718 | 0.93 | CYP1A2 (0.37) | CYP1A2TLR8HRH4MEN1KMT2A | |
| SCHEMBL7682669 | 0.82 | TRPV1 (0.36) | CYP1A2KMT2AHSD11B1ALDH1A1MAPT | |
| SCHEMBL7673287 | 0.81 | RAB9A (0.49) | CYP1A2HRH4 | |
| SCHEMBL7681496 | 0.81 | SMN1; SMN2 (0.43) | CYP1A2HRH4 | |
| SCHEMBL27434416 | 0.79 | CYP1A2 (0.35) | CYP1A2MEN1KMT2AHSD11B1ALDH1A1 | |
| SCHEMBL7824628 | 0.77 | P2RX7 (0.33) | HRH4 | |
| SCHEMBL8784616 | 0.74 | TLR8 (0.35) | TLR8HRH4ALDH1A1 | |
| SCHEMBL7676533 | 0.73 | HRH4 (0.36) | HRH4 | |
| SCHEMBL7680475 | 0.71 | HRH4 (0.36) | HRH4 | |
| SCHEMBL8784365 | 0.68 | HRH4 (0.34) | HRH4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |