Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 6/20 | 0.47 |
| ▸ | AKT2 | P31751 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673955 | 0.91 | NPC1 (0.42) | AKT1AKT2USP7MAPTCDK2 | |
| SCHEMBL7676761 | 0.91 | AKT1 (0.51) | AKT1AKT2ALDH1A1ALDH1A3USP7 | |
| SCHEMBL7679500 | 0.91 | CDK2 (0.43) | AKT1AKT2USP7CDK2TRPM8 | |
| SCHEMBL7680199 | 0.89 | TLR7 (0.39) | AKT1AKT2USP7MAPTCDK2 | |
| SCHEMBL7682045 | 0.89 | CDK2 (0.43) | AKT1AKT2ALDH1A1USP7MAPT | |
| SCHEMBL7677596 | 0.88 | CDK2 (0.41) | AKT1AKT2USP7MAPTNPSR1 | |
| SCHEMBL7680034 | 0.88 | CDK2 (0.40) | AKT1AKT2USP7MAPTCDK2 | |
| SCHEMBL7674349 | 0.88 | TRPV1 (0.40) | USP7CDK2CDK4 | |
| SCHEMBL7680009 | 0.85 | CDK2 (0.39) | AKT1AKT2USP7CDK2RAB9A | |
| SCHEMBL7676765 | 0.85 | POLB (0.46) | ALDH1A1MAPTCYP2C9CYP2C19CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358971-B1 | FOR INHIBITING THE GROWTH OF A PICORNAVIRUS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |