SCHEMBL7675174

SCHEMBL7675174

CSc1cccc(NC(=O)c2nc(C)ccc2C(=O)O)c1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
KDM4E B2RXH2 2/20 0.46
CA12 O43570 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
KMT2A Q03164 2/20 0.46
ALOX15 P16050 2/20 0.44
HSD17B10 Q99714 4/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
TP53 P04637 2/20 0.42
HPGD P15428 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9214998 0.78 KDM4E (0.53) KDM4ECA12CA2CA9KMT2A
SCHEMBL7675185 0.74 CA12 (0.42) ALDH1A1KDM4ECA12CA2CA9
SCHEMBL7466102 0.72 ALDH1A1 (0.50) ALDH1A1KMT2AHSD17B10RAB9AMAPT
SCHEMBL2427544 0.70 POLB (0.50) ALDH1A1KDM4ECA12CA2CA9
SCHEMBL29625359 0.69 GABRP (0.47) ALDH1A1KDM4EKMT2AALOX15MAPT
SCHEMBL262422 0.69 GABRP (0.47) ALDH1A1KDM4EKMT2AALOX15MAPT
SCHEMBL9216226 0.68 KDM4E (0.46) ALDH1A1KDM4EHPGDGRM5SORT1
SCHEMBL28545196 0.68 GABRP (0.46) ALDH1A1KDM4EKMT2AALOX15MAPT
SCHEMBL6739536 0.67 SORT1 (0.40) KDM4ECA12CA2CA9GRM5
SCHEMBL6573965 0.66 GABRP (0.44) ALDH1A1KDM4EKMT2AALOX15MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6472349-B1 Pyridine-2,3-dicarboxylic acid diamides BASF AKTIENGESELLSCHAFT (DE) 2002-10-29 US disclosed