SCHEMBL7675454

SCHEMBL7675454

CC[S+]([O-])c1c(C(N)=S)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GABRP O00591 19/20 0.46
▸ GABRD O14764 19/20 0.46
▸ GABRA1 P14867 19/20 0.46
▸ GABRB1 P18505 19/20 0.46
▸ GABRG2 P18507 19/20 0.46
▸ GABRB3 P28472 19/20 0.46
▸ GABRA5 P31644 19/20 0.46
▸ GABRA3 P34903 19/20 0.46
▸ GABRA2 P47869 19/20 0.46
▸ GABRB2 P47870 19/20 0.46
▸ GABRA4 P48169 19/20 0.46
▸ GABRE P78334 19/20 0.46
▸ GABRA6 Q16445 19/20 0.46
▸ GABRG1 Q8N1C3 19/20 0.46
▸ GABRG3 Q99928 19/20 0.46
▸ GABRQ Q9UN88 19/20 0.46
▸ ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7675094 0.93 GABRP (0.43) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7026796 0.89 GABRP (0.44) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL5203598 0.88 GABRP (0.48) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7667746 0.88 GABRP (0.49) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7667667 0.86 GABRP (0.37) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7026790 0.85 GABRP (0.44) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7242822 0.85 GABRP (0.43) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL33214 0.85 GABRP (0.52) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL13442984 0.85 GABRB3 (0.51) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7707169 0.84 GABRB3 (0.50) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020016468-A1 PESTICIDAL 1-ARYLPYRAZOLE DERIVATIVES RHONE-POULENC AGROCHIMIE (FR) 2002-02-07 — — US claimed
US-9609871-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-04-04 — — US disclosed
US-9609871-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-04-04 — — US disclosed
EP-2104426-B1 AGENTS FOR CONTROLLING PARASITES ON ANIMALS BAYER IP GMBH (DE) 2016-03-30 — — EP disclosed
US-20160007611-A1 Combination product for controlling parasites on animals ELANCO ANIMAL HEALTH GMBH (DE) 2016-01-14 — — US disclosed
US-20160007611-A1 Combination product for controlling parasites on animals ELANCO ANIMAL HEALTH GMBH (DE) 2016-01-14 — — US disclosed
EP-2104428-B1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER IP GMBH (DE) 2015-10-14 — — EP disclosed
US-9137995-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-09-22 — — US disclosed
US-9137995-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-09-22 — — US disclosed
US-20130045996-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2013-02-21 — — US disclosed
US-8071116-B2 Combination product for controlling parasites on animals BAYER ANIMAL HEALTH GMBH (DE) 2011-12-06 — — US disclosed
US-20100016398-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2010-01-21 — — US disclosed
US-20100016398-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2010-01-21 — — US disclosed
US-20090312387-A1 COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2009-12-17 — — US disclosed
US-20090312387-A1 COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2009-12-17 — — US disclosed
WO-2008080542-A2 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2008-07-10 — — WO disclosed
WO-2008080541-A1 AGENTS FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2008-07-10 — — WO disclosed
US-20020016468-A1 PESTICIDAL 1-ARYLPYRAZOLE DERIVATIVES RHONE-POULENC AGROCHIMIE (FR) 2002-02-07 — — US disclosed
EP-0948487-A1 PESTICIDAL 1-ARYL AND PYRIDYLPYRAZOLE DERIVATIVES RHONE-POULENC AGROCHIMIE (FR) 1999-10-13 — — EP disclosed
WO-1998028279-A1 PESTICIDAL 1-ARYL AND PYRIDYLPYRAZOLE DERIVATIVES RHONE-POULENC AGROCHIMIE (FR) 1998-07-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160007611-A1 Combination product for controlling parasites on animals CYCS, CYP3A43, CDIPT GABRP 68/4885GABRD 346/4885GABRA1 385/4885
US-20100016398-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS CYCS, CYP3A43, CDIPT GABRP 68/4885GABRD 346/4885GABRA1 385/4885
US-20130045996-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS CYCS, CYP3A43, CDIPT GABRP 68/4885GABRD 346/4885GABRA1 385/4885
US-20020016468-A1 PESTICIDAL 1-ARYLPYRAZOLE DERIVATIVES DDT, NAT1, CYP2E1 GABRP 1003/4885GABRD 1930/4885GABRA1 1418/4885
US-20090312387-A1 COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS CYCS, PTMS, PLCB3 GABRP 687/4885GABRD 3073/4885GABRA1 2122/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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