Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR1B | P28222 | 3/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368952 | 0.77 | NAMPT (0.36) | NAMPTLIPEHTR1DHTR1BPDK4 | |
| SCHEMBL7666251 | 0.74 | NAMPT (0.40) | NAMPTF2WNT3AKMT2A | |
| SCHEMBL7671538 | 0.73 | PDK4 (0.44) | NAMPTLIPEMEN1KMT2AHTR6 | |
| SCHEMBL20605254 | 0.72 | LIPE (0.40) | LIPEDRD2MEN1KMT2A | |
| SCHEMBL30478686 | 0.71 | TBK1 (0.33) | NAMPTLIPEHTR1DHTR1BKMT2A | |
| SCHEMBL30478691 | 0.71 | TBK1 (0.33) | NAMPTLIPEHTR1DHTR1BKMT2A | |
| SCHEMBL702839 | 0.68 | CYP17A1 (0.58) | NAMPTCYP17A1DRD2MEN1KMT2A | |
| SCHEMBL694492 | 0.68 | L3MBTL1 (0.53) | NAMPT | |
| SCHEMBL22340252 | 0.68 | NAMPT (0.55) | NAMPTWNT3AKITHTR6PDK4 | |
| SCHEMBL17876418 | 0.67 | NAMPT (0.57) | NAMPTWNT3AHTR6PDK4CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365602-B1 | FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS | ASTRA ZENECA AB (SE) | 2002-04-02 | — | — | US | disclosed |