Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | HTR7 | P34969 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681474 | 0.98 | HTR1A (0.58) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7681408 | 0.94 | HTR1A (0.50) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7681588 | 0.85 | HTR1A (0.58) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7681457 | 0.83 | HTR1A (0.60) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL8101997 | 0.80 | DRD4 (0.65) | HTR1AHTR7DRD2HTR2ADRD3 | |
| SCHEMBL7689812 | 0.79 | MAPT (0.73) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7684230 | 0.78 | HTR1A (0.52) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7689917 | 0.77 | MAPT (0.73) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL8598448 | 0.76 | HTR1A (0.57) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL8102136 | 0.76 | CTSS (0.67) | HTR1AHTR7DRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413966-B1 | SEROTONERGIC AND CENTRAL DOPAMINERGIC ACTIVITY; AFFINITY FOR 5HT1A AND 5HT2 SEROTONIN AND D2 DOPAMINE RECEPTORS; ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIA | FAES, FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. | 2002-07-02 | — | — | US | claimed |
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |