Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 4/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103525 | 0.98 | HTR2A (0.65) | CTSSHTR2ASLC6A4DRD2HTR7 | |
| SCHEMBL8103915 | 0.94 | CTSS (0.60) | CTSSHTR2ASLC6A4DRD2HTR7 | |
| SCHEMBL7689812 | 0.86 | MAPT (0.73) | CTSSHTR2ASLC6A4DRD2HTR7 | |
| SCHEMBL8109562 | 0.86 | DRD2 (0.58) | CTSSHTR2ASLC6A4DRD2HTR7 | |
| SCHEMBL8103844 | 0.85 | HTR2A (0.65) | CTSSHTR2ASLC6A4DRD2HTR7 | |
| SCHEMBL7689917 | 0.84 | MAPT (0.73) | HTR2ASLC6A4DRD2HTR7HTR1A | |
| SCHEMBL8103442 | 0.83 | HTR2A (0.68) | HTR2ASLC6A4DRD2HTR7HTR1A | |
| SCHEMBL7683387 | 0.79 | MAPT (0.72) | HTR2ASLC6A4DRD2HTR7HTR1A | |
| SCHEMBL11465528 | 0.79 | SIGMAR1 (0.76) | HTR2ADRD2HTR7HTR1ASIGMAR1 | |
| SCHEMBL8107948 | 0.79 | HTR2A (0.59) | HTR2ASLC6A4DRD2HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |