Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 7/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689917 | 0.98 | MAPT (0.73) | MAPTHTR1AHTR7HSD17B10KDM4E | |
| SCHEMBL7683387 | 0.94 | MAPT (0.72) | MAPTHTR1AHTR7HSD17B10KDM4E | |
| SCHEMBL8108057 | 0.87 | HTR1A (0.61) | MAPTHTR1AHTR7HSD17B10KDM4E | |
| SCHEMBL8102136 | 0.86 | CTSS (0.67) | MAPTHTR1AHTR7SIGMAR1DRD2 | |
| SCHEMBL8103814 | 0.85 | HTR1A (0.63) | MAPTHTR1AHTR7HSD17B10KDM4E | |
| SCHEMBL8103525 | 0.84 | HTR2A (0.65) | MAPTHTR1AHTR7SIGMAR1DRD2 | |
| SCHEMBL7689489 | 0.84 | KCNH2 (0.61) | MAPTHTR1AHTR7HSD17B10KDM4E | |
| SCHEMBL7685556 | 0.81 | KCNH2 (0.64) | HTR1AHTR7HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8103915 | 0.79 | CTSS (0.60) | MAPTHTR1AHTR7KCNH2SIGMAR1 | |
| SCHEMBL7679341 | 0.79 | HTR1A (0.56) | MAPTHTR1AHTR7DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413966-B1 | SEROTONERGIC AND CENTRAL DOPAMINERGIC ACTIVITY; AFFINITY FOR 5HT1A AND 5HT2 SEROTONIN AND D2 DOPAMINE RECEPTORS; ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIA | FAES, FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. | 2002-07-02 | — | — | US | claimed |
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |