SCHEMBL7689917

SCHEMBL7689917

O=c1ccc(-c2ccccc2)nn1CCCCN1CCN(c2cccc(Cl)c2)CC1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.73
HTR1A P08908 6/20 0.67
HTR7 P34969 3/20 0.67
KCNH2 Q12809 2/20 0.60
DRD2 P14416 2/20 0.58
HTR2A P28223 2/20 0.58
HTR6 P50406 1/20 0.58
HSD17B10 Q99714 3/20 0.57
SIGMAR1 Q99720 2/20 0.57
KDM4E B2RXH2 2/20 0.57
ALDH1A1 P00352 2/20 0.57
HPGD P15428 2/20 0.57
ABCB11 O95342 1/20 0.57
LMNA P02545 1/20 0.57
ADRA2A P08913 1/20 0.57
CYP2D6 P10635 1/20 0.57
ADRA2B P18089 1/20 0.57
ADRA2C P18825 1/20 0.57
DRD1 P21728 1/20 0.57
DRD4 P21917 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7689812 0.98 MAPT (0.73) MAPTHTR1AHTR7KCNH2DRD2
SCHEMBL7683387 0.94 MAPT (0.72) MAPTHTR1AHTR7KCNH2DRD2
SCHEMBL8103814 0.87 HTR1A (0.63) MAPTHTR1AHTR7KCNH2DRD2
SCHEMBL8103525 0.86 HTR2A (0.65) MAPTHTR1AHTR7DRD2HTR2A
SCHEMBL8108057 0.85 HTR1A (0.61) MAPTHTR1AHTR7KCNH2DRD2
SCHEMBL8102136 0.84 CTSS (0.67) MAPTHTR1AHTR7DRD2HTR2A
SCHEMBL7685556 0.84 KCNH2 (0.64) HTR1AHTR7KCNH2DRD2HTR2A
SCHEMBL7689489 0.81 KCNH2 (0.61) MAPTHTR1AHTR7KCNH2DRD2
SCHEMBL8103915 0.79 CTSS (0.60) MAPTHTR1AHTR7KCNH2DRD2
SCHEMBL7681474 0.79 HTR1A (0.58) MAPTHTR1AHTR7DRD2HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6413966-B1 SEROTONERGIC AND CENTRAL DOPAMINERGIC ACTIVITY; AFFINITY FOR 5HT1A AND 5HT2 SEROTONIN AND D2 DOPAMINE RECEPTORS; ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIA FAES, FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. 2002-07-02 US claimed