Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7679536 | 1.00 | SLC9A1 (0.39) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| Fumaric Acid SCHEMBL7591475 | 1.00 | SLC9A1 (0.39) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| SCHEMBL7679914 | 0.89 | SLC9A1 (0.40) | SLC9A1ALDH1A1MAPTTSHRHPGD | |
| SCHEMBL7595671 | 0.89 | SLC9A1 (0.40) | SLC9A1ALDH1A1MAPTTSHRHPGD | |
| Fumaric Acid SCHEMBL7592486 | 0.89 | SLC9A1 (0.38) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| Fumaric Acid SCHEMBL7591644 | 0.89 | SLC9A1 (0.38) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| Fumaric Acid SCHEMBL7589104 | 0.83 | ALDH1A1 (0.35) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| Fumaric Acid SCHEMBL7589109 | 0.83 | ALDH1A1 (0.35) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| Fumaric Acid SCHEMBL7589099 | 0.83 | ALDH1A1 (0.35) | SLC9A1RAB9AHCAR2ALDH1A1TAAR1 | |
| Oxalic Acid SCHEMBL7689014 | 0.80 | SLC9A1 (0.40) | SLC9A1ALDH1A1MAPTTSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451789-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | LES LABORTOIRES SERVIER (FR) | 2002-09-17 | — | — | US | disclosed |
| US-6323222-B1 | COGNITION ACTIVATORS, ALZHEIMER*S DISEASE AND ENZYME INHIBITORS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |