Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891994 | 0.87 | KIF11 (0.46) | KIF11MEN1KMT2AHTR6CHUK | |
| SCHEMBL30532272 | 0.87 | CYP2C9 (0.47) | KIF11MEN1KMT2ACHUKCYP1A2 | |
| SCHEMBL892668 | 0.87 | CYP2C9 (0.47) | KIF11MEN1KMT2ACHUKCYP1A2 | |
| SCHEMBL15313180 | 0.82 | KIF11 (0.43) | KIF11MEN1KMT2AHTR6CHUK | |
| SCHEMBL7698333 | 0.77 | ALDH1A1 (0.43) | KIF11MEN1KMT2AKDM4E | |
| SCHEMBL14499883 | 0.72 | GHSR (0.43) | KIF11MEN1KMT2ACHUKHSD17B10 | |
| SCHEMBL22417826 | 0.71 | MEN1 (0.54) | KIF11MEN1KMT2AHTR6CHUK | |
| SCHEMBL4951539 | 0.70 | HTT (0.40) | KIF11MEN1KMT2ACHUKHSD17B10 | |
| SCHEMBL18932887 | 0.69 | ALDH1A1 (0.44) | KIF11MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL412032 | 0.67 | KIF11 (0.81) | KIF11MEN1KMT2ACHUKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |