Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30532272 | 1.00 | CYP2C9 (0.47) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7679735 | 0.87 | KIF11 (0.46) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL891994 | 0.87 | KIF11 (0.46) | MEN1KMT2AKIF11CHUKEGFR | |
| SCHEMBL4951539 | 0.84 | HTT (0.40) | MEN1KMT2AKIF11CHUKKDM4E | |
| SCHEMBL18932887 | 0.82 | ALDH1A1 (0.44) | MEN1KMT2AKIF11EGFRKDM4E | |
| SCHEMBL15313180 | 0.82 | KIF11 (0.43) | MEN1KMT2AKIF11CHUKEGFR | |
| SCHEMBL892954 | 0.78 | MEN1 (0.53) | CYP2C9MEN1KMT2ACHUKALDH1A1 | |
| SCHEMBL3925023 | 0.78 | MAP4K1 (0.34) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7698333 | 0.77 | ALDH1A1 (0.43) | MEN1KMT2AKIF11KDM4EALDH1A1 | |
| SCHEMBL14499883 | 0.72 | GHSR (0.43) | MEN1KMT2AKIF11CHUKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4406957-B1 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | NOGRA PHARMA LTD (IE) | 2026-04-08 | — | — | EP | disclosed |
| US-12577256-B2 | Aryl receptor modulators and methods of making and using the same | NOGRA PHARMA LIMITED (IE) | 2026-03-17 | — | — | US | disclosed |
| US-20250066384-A1 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | NOGRA PHARMA LIMITED (IE) | 2025-02-27 | — | — | US | disclosed |
| EP-4406957-A2 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | Nogra Pharma Limited (IE) | 2024-07-31 | — | — | EP | disclosed |
| US-12012418-B2 | Aryl receptor modulators and methods of making and using the same | NOGRA PHARMA LIMITED (IE) | 2024-06-18 | — | — | US | disclosed |
| EP-3160964-B1 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | NOGRA PHARMA LTD (IE) | 2024-03-13 | — | — | EP | disclosed |
| CN-116947880-A | Aryl receptor modulators and methods of making and using the same | 诺格拉制药有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-111978319-B | Aryl receptor modulators and methods of making and using the same | 诺格拉制药有限公司 | 2023-08-11 | — | — | CN | disclosed |
| US-20230234963-A1 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | NOGRA PHARMA LIMITED (IE) | 2023-07-27 | — | — | US | disclosed |
| US-11427600-B2 | Aryl receptor modulators and methods of making and using the same | NOGRA PHARMA LIMITED (IE) | 2022-08-30 | — | — | US | disclosed |
| EP-2651887-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven K.U. Leuven R&D (BE) | 2013-10-23 | — | — | EP | disclosed |
| EP-2651888-A1 | NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven K.U. Leuven R&D (BE) | 2013-10-23 | — | — | EP | disclosed |
| US-20130274260-A1 | NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | REMYND (BE) | 2013-10-17 | — | — | US | disclosed |
| CN-103261156-A | New compounds for the treatment of neurodegenerative diseases | LEUVEN K U RES & DEV | 2013-08-21 | — | — | CN | disclosed |
| CN-102803252-A | Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases | UNIV LEUVEN KATH | 2012-11-28 | — | — | CN | disclosed |
| WO-2012080220-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080221-A1 | NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-21 | — | — | WO | disclosed |
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-04-05 | — | — | US | disclosed |
| WO-2010142801-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12577256-B2 | Aryl receptor modulators and methods of making and using the same | AHR, IL23R, ARNT | CYP2C9 486/4885CYP1A2 192/4885CYP3A4 697/4885 |
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, MAPT, NLN | CYP2C9 4482/4885CYP1A2 3183/4885CYP3A4 3828/4885 |
| US-20250066384-A1 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | AHR, IFNAR1, IL23R | CYP2C9 272/4885CYP1A2 85/4885CYP3A4 210/4885 |
| US-20130274260-A1 | NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, MAPT, PSEN1 | CYP2C9 4382/4885CYP1A2 3641/4885CYP3A4 3772/4885 |
| US-12012418-B2 | Aryl receptor modulators and methods of making and using the same | AHR, IL23R, IL2RA | CYP2C9 311/4885CYP1A2 69/4885CYP3A4 213/4885 |
| US-11427600-B2 | Aryl receptor modulators and methods of making and using the same | AHR, IL23R, IL2RA | CYP2C9 311/4885CYP1A2 69/4885CYP3A4 213/4885 |
| US-20230234963-A1 | ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME | AHR, IL23R, IL2RA | CYP2C9 311/4885CYP1A2 69/4885CYP3A4 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.