Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677748 | 0.96 | SIGMAR1 (0.54) | SIGMAR1HTR7DRD2DRD3DRD5 | |
| SCHEMBL12468732 | 0.84 | DRD2 (0.54) | SIGMAR1HTR7DRD2DRD3DRD5 | |
| SCHEMBL4608504 | 0.83 | HTR7 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL12469317 | 0.82 | NPSR1 (0.61) | SIGMAR1HTR7DRD2DRD3DRD5 | |
| SCHEMBL4608940 | 0.81 | ALDH1A1 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL7677755 | 0.79 | SIGMAR1 (0.55) | SIGMAR1HTR7DRD2DRD3DRD5 | |
| SCHEMBL11465528 | 0.78 | SIGMAR1 (0.76) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL9540044 | 0.78 | SIGMAR1 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL12468893 | 0.77 | SIGMAR1 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL7680687 | 0.77 | SMN1; SMN2 (0.59) | SIGMAR1HTR7DRD2DRD3DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403593-B1 | DOPAMINE RECEPTOR | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| US-6124294-A | COMPOUNDS HAVING HIGH AFFINITY FOR DOPAMINE D3 RECEPTOR; USED TO TREAT DISORDERS WHICH RESPOND TO DOPAMINE D3 LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-09-26 | — | — | US | disclosed |
| EP-0772604-B1 | TRIAZOLE COMPOUNDS AND THEIR USE AS DOPAMINE-D3-LIGANDS | BASF AG (DE) | 1999-05-06 | — | — | EP | disclosed |