Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682012 | 1.00 | MAPK1 (0.49) | MAPK1TSHRAPPVCAM1L3MBTL1 | |
| SCHEMBL15075930 | 0.87 | ALDH1A1 (0.56) | MAPK1TSHRAPPL3MBTL1CYP1A2 | |
| SCHEMBL5205743 | 0.85 | PKM (0.45) | MAPK1TSHRAPPL3MBTL1CYP1A2 | |
| SCHEMBL624054 | 0.81 | ALDH1A1 (0.64) | MAPK1TSHRAPPL3MBTL1CYP1A2 | |
| SCHEMBL7673660 | 0.80 | ALDH1A1 (0.62) | MAPK1TSHRAPPL3MBTL1CYP1A2 | |
| SCHEMBL2494783 | 0.80 | CYP1A2 (0.41) | MAPK1TSHRCYP1A2PDK1ALDH1A1 | |
| SCHEMBL7043142 | 0.80 | CASP6 (0.64) | TSHRPDK1 | |
| SCHEMBL7043138 | 0.80 | CASP6 (0.64) | TSHRPDK1 | |
| SCHEMBL7047455 | 0.80 | ALOX15 (0.54) | MAPK1TSHRL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1223088 | 0.80 | CYP1A2 (0.44) | MAPK1TSHRCYP1A2PDK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093928-A1 | AN IMPROVED PROCESS FOR PREPARING 2-OXINDOLES OF FORMULA I, A KEY RAW MATERIAL FOR MAKING PHARMACEUTICAL DRUGS AND INTERMEDIATES THEREOF | ARCH PHARMALABS LIMITED (IN) | 2013-06-27 | — | — | WO | disclosed |
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |