Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683237 | 0.82 | SMN1; SMN2 (0.48) | HCAR2TP53RECQLSMN1; SMN2MAPT | |
| SCHEMBL7682652 | 0.80 | HCAR2 (0.42) | HCAR2TP53RECQLSMN1; SMN2MAPT | |
| SCHEMBL7689472 | 0.79 | LMNA (0.47) | HCAR2TP53RECQLSMN1; SMN2MAPT | |
| SCHEMBL7681257 | 0.76 | SMN1; SMN2 (0.45) | HCAR2TP53RECQLSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7690432 | 0.74 | HCAR2 (0.43) | HCAR2HPGDLMNA | |
| Hydrochloric Acid SCHEMBL7690433 | 0.74 | HCAR2 (0.43) | HCAR2HPGDLMNA | |
| SCHEMBL23657917 | 0.72 | ALPL (0.56) | TP53MAPTHPGDLMNAALDH1A1 | |
| SCHEMBL7690336 | 0.72 | HPGD (0.46) | TP53RECQLSMN1; SMN2MAPTHPGD | |
| SCHEMBL7689656 | 0.71 | TP53 (0.49) | HCAR2TP53RECQLSMN1; SMN2MAPT | |
| SCHEMBL7678959 | 0.70 | SMN1; SMN2 (0.49) | HCAR2TP53RECQLSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |