Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 2/20 | 0.42 |
| ▸ | LDHB | P07195 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680997 | 0.87 | HTR2C (0.41) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7683083 | 0.84 | MAP1LC3B (0.39) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7688025 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7685234 | 0.80 | ALOX15 (0.56) | SMN1; SMN2ALDH1A1LMNAHTTTP53 | |
| SCHEMBL7689656 | 0.80 | TP53 (0.49) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7683237 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL16217087 | 0.74 | LMNA (0.69) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7681186 | 0.73 | TP53 (0.48) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7689638 | 0.73 | TP53 (0.48) | SMN1; SMN2ALDH1A1LMNAHTTRXFP1 | |
| SCHEMBL7689215 | 0.73 | TSHR (0.55) | SMN1; SMN2ALDH1A1LMNAHTTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |